186: NAD+, Sirtuins, and the 4 Root Causes of Aging
NAD+ is usually described as something you run out of. JP Errico explains why that's backwards: you don't stop making it, you burn through it — and inflammation is what's doing the burning.
In this episode, we cover what NAD+ actually does beyond energy production, why sirtuins can't function without it, and how CD38 on activated immune cells consumes NAD+ by the thousands of molecules. JP walks through SIRT1 and its control over NF-κB, PGC-1α and FOXO3; SIRT3's role in mitochondrial protein folding and heat shock proteins; and SIRT6's work in DNA damage repair.
We also get into a CD38 vaccine coming out of China, how your body packages the NAMPT recycling enzyme into exosomes and ships it to the cells that need it while you sleep, where urolithin A and methylene blue fit, and why no supplement can out-run a broken circadian rhythm.
JP closes with the four root causes of aging — mitochondrial electron transport chain malfunction, chronic NF-κB activation, AMPK and mTOR imbalance, and NAD+ depletion — and why every one of them is reversible.
In this episode, we discuss:
- Why NAD+ decline is a consumption problem, not a production problem
- PARP1, CD38, and what's actually draining the tank
- What sirtuins do, and why they stop working without NAD+
- SIRT1, SIRT3, SIRT6 — and which has the best longevity data
- NMN vs NR: why the debate matters less than you think
- Sleep, fasting, heat and exercise as the foundation
- The four reversible root causes of aging
- How perception changes whether a challenge ages you or strengthens you
Dr. Navaz Habib
Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib
JP Errico
Instagram: https://www.instagram.com/thevnsguy/
LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib
JP Errico
Instagram: https://www.instagram.com/thevnsguy/
LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa
Creators and Guests
Host
JP Errico
Key Strategic Advisor. JP provides capital markets and strategic advisory services to companies, Boards, and management teams covering several areas of expertise, including access to both private and public capital markets, clinical and regulatory affairs, R&D, manufacturing, M&A negotiations and integration, Board governance, and intellectual property portfolio management.
Host
Navaz Habib
Author, Speaker, Founder of Health Upgraded. Helping high performers address inflammation and health challenges by activating their Vagus Nerve.
